L-citrulline – Review the Latest Research

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L-citrulline is an amino acid that is not essential. The kidneys convert L-citrulline to an amino acid known as L-arginine and into a chemical known as Nitric oxide.

These chemicals are essential to heart and blood vessel health and can also help boost the immune system.

Why do people take L-citrulline?

L-citrulline increases the production of nitric oxide throughout the body. Nitric oxide assists your arteries in relaxing and functioning better and improves circulation throughout your body. It can help treat or prevent certain illnesses.

Evidence suggests the supplement might reduce blood pressure in those with high blood pressure. High blood pressure can increase the risk of the heart and blood vessels becoming clogged. The definitions of blood pressure include:

  • Normal blood pressure is less than 120, but not more than 80(<120/<80)
  • Elevated: 120-129 in the lower limit of 80 (120-129/<80)
  • Stage 1 of hypertension 130-139 or 80-89
  • Stage 2 of hypertension: greater than 140 or more than 90 (>=140 or >90).

L-citrulline supplements can ease the symptoms of moderate-to-moderate erectile disorder (ED). The scientists say that L-citrulline may not perform as effectively as ED medications such as Viagra. However, it is believed to be a secure alternative.

Studies in animals suggest that L-citrulline may aid people suffering from blood vessel issues, such as slow wound healing caused by diabetes.

Another animal study suggests that L-citrulline may increase the levels of muscle protein and help reduce malnutrition in the elderly.

The research on animals also suggests that L-citrulline can help treat digestive issues, such as:

  • Short bowel syndrome
  • Celiac disease
  • Small bowel injuries caused by radiation

Supplements could help certain genetic diseases and conditions like liver disease with L-citrulline.

Human studies have always suggested that L-citrulline could be beneficial in the treatment of Parkinson's disease and other dementias.

Many users also take L-citrulline to strengthen muscles and boost athletic performance. However, studies show it doesn't help trained athletes to perform better or exercise more effectively.

The supplement typically comes in the form of powder. The recommended dosage for L-citrulline varies based on the condition you're trying to prevent or treat. However, it is often utilized as much as 6 grams daily for up to 16 consecutive days. However, the ideal dosages of L-citrulline are not established for any specific condition. The activity and quality of the ingredients in supplements can differ widely, making it difficult to determine a consistent dose.

Do you have the ability to get L-citrulline naturally in foods?

Yes, watermelon does contain L-citrulline.

What are the dangers of taking L-citrulline?

There are no known side consequences of L-citrulline.

However, it could alter how certain medications are administered to your body. Avoid taking this supplement if you're taking:

  • Nitrates to fight heart disease
  • ED medications like sildenafil (Revatio, Viagra), tadalafil (Cialis), or Vardenafil (Levitra, Staxyn)

Combining L-citrulline and these drugs can cause a risky decrease in blood pressure.

Be aware of this while taking L-citrulline or other blood pressure medication.

Do not take L-citrulline when you are nursing or pregnant.

Always inform your doctor about any supplements you take. So your doctor can check for possible adverse effects or interactions with medicines.

The U.S. Food and Drug Administration (FDA) regulates diet supplements. However, they are treated differently than food and drugs. The manufacturer is accountable for the safety and correct marking of their products.

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